I have a HOTAS system plugged into my PC (four separate USB devices). I have selected to disable controllers in the settings thus relying on mouse and keyboard only. This works correctly in-game, but in the game menu I do get possible interference from my controllers in the Exploration mode load screen. The highlighted section of the available save games will always move to the top (which is the create new game option). The only way to load my existing game is to double-click on my save game. This is not an issue for just loading an existing save, but it there are other actions that can be performed on an existing save, I would not be able to select these.
To summarise, I cannot load a save game by selecting it and pressing the play button, as the selection always moves up to the top by itself and changes the context of the load button to create new.